Amatem Forte. Antimalaria Drug-Tab

Artemether 80 mg and Lumefantrine 480 mg

(often sold under brand names like Amatem Forte, Artemef, or Coartem) is a high-strength, fixed-dose artemisinin-based combination therapy (ACT) used to treat acute, uncomplicated malaria.

The “80/480” formulation is a double-strength dose designed primarily for adults and adolescents weighing 35 kg (approx. 77 lbs) or more. This combined strength reduces the total pill burden, allowing patients to take just one tablet per dose instead of four standard-strength (20/120 mg) tablets.

• Artemether (80 mg): A fast-acting component that rapidly kills the parasites and provides immediate relief from symptoms like fever and chills within 48 to 72 hours. 
• Lumefantrine (480 mg): A much slower-acting but long-lasting clearing agent that stays in the body for days to completely eliminate any remaining parasites and prevent a relapse.
• Standard Dosage and Administration
  For adults and individuals weighing over 35 kg, the standard course consists of 6 doses taken over 3 days (6 tablets total): 
  • Day 1: Take 1 tablet immediately upon diagnosis, followed by a 2nd tablet exactly 8 hours later.
  • Day 2: Take 1 tablet in the morning and 1 tablet in the evening (12 hours apart).

  • Day 3: Take 1 tablet in the morning and 1 tablet in the evening (12 hours apart).

Crucial Rule:

Always take this medication with fatty food or a milky drink (such as whole milk, yoghurt, or a meal containing oil/butter). Fat is absolutely necessary for the body to properly absorb the lumefantrine component. If you vomit within 1 to 2 hours of taking a dose, you must take a replacement dose